While the gut microbiota of adults is typically constant, changes have been observed from dietary interventions ( 6), including with polyphenol supplementation. The microbiota are known to metabolize many polyphenols, altering their bioavailability ( 4), providing energy and metabolites to surrounding enterocytes, and decreasing systemic inflammation ( 5). Polyphenols are often found in fruits, spices and herbs, vegetables, and drinks. Evidence suggests a diet high in polyphenols and or supplementation with polyphenol-containing supplements can improve risk of developing type 2 diabetes ( 2), which may be in part be due to the gut microbiota ( 3). Globally the incidence of type 2 diabetes is rising and is predicted to rise to nearly 700 million by 2,045 ( 1). These data suggest that 30 days of MTC supplementation does not modulate the gut microbiome, inflammation, or improve glycemic control in a healthy, diverse group of adults.Ĭlinical Trail Registration:, identifier: NCT04467372.Ī considerable amount of research has focused on the use of foods and supplements containing anthocyanins and polyphenols to reduce disease risk by mitigating inflammation and improving blood glucose regulation. There was no significant change in composition of bacterial phyla, families, or subfamilies for the duration of this study nor was there a change in species richness. L −1) but this was no different between groups ( p = 0.33).Insulin was not changed over time ( p = 0.16) or between groups ( p = 0.24), nor was glycated albumin different over time ( p = 0.08) or between groups ( p = 0.56), however glucose levels increased ( p < 0.001) from baseline (4.79 ± 1.00 mmol 14 days ( p = 0.01), however there was no other significant change in the inflammatory markers. TNF-alpha was significantly lower at 30 vs. A fecal sample was provided at baseline, day 14 and 30 for microbiome analysis. Venous blood samples were drawn at baseline, day 7, 14, and 30 and analyzed for inflammatory markers TNF-alpha, uric acid, C-reactive protein, and erythrocyte sedimentation rate and glycemic control markers glycated albumin, glucose and insulin. Healthy participants with no known disease ( n = 58, age: 28 ± 10 y, height: 169.76 ± 8.55 cm, body mass: 72.2 ± 12.9 kg) were randomly allocated to four groups and consumed either concentrate or freeze-dried capsules or their corresponding placebos for 30 days. Therefore, the purpose of this study was to investigate the effect of 30 days of supplementation with Montmorency tart cherry (MTC) in concentrate or freeze-dried form on the gut microbiome and markers of inflammation and glycemic control. Processing (i.e., juice concentrate, dried, frozen) may affect the properties of tart cherries, and therefore alter their efficacious health benefits. Tart cherries possess properties that may reduce inflammation and improve glycemic control, however human data on supplementation and the gut microbiota is equivocal. 2College of Education, Department of Physical Education, Qatar University, Doha, Qatar.1School of Applied Health Sciences and Wellness, Division of Exercise Physiology, Ohio University, Athens, OH, United States.
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